amyloid disease造句

• Type 2 diabetes is also an amyloid disease.
• Treatment of familial TTR amyloid disease has historically relied on liver transplantation as a crude form of gene therapy.
• The Kelly laboratory discovered the first regulatory agency-approved drug that slows the progression of a human amyloid disease using a structure-based design approach.
• Collectively, the tafamidis and diflunisal data provide compelling pharmacologic evidence supporting the amyloid hypothesis, the idea that active transthyretin aggregation causes the loss of post-mitotic tissue in this degenerative amyloid disease.
• 2003 Hammarstrom, P .; Wiseman, R . L .; Powers, E . T .; Kelly, J . W . " Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics " Science 299, 713-716.
• The modern classification of amyloid disease tends to use an abbreviation of the protein that makes the majority of deposits, prefixed with the letter A . For example, amyloidosis caused by transthyretin is termed " ATTR ".
• Although the alpha sheet is only rarely observed in natural protein structures, it has been speculated to play a role in amyloid disease and it was found to be a stable form for amyloidogenic proteins in one set of molecular dynamics simulations.